Description

1-Chloroisoquinoline-5-Sulfonyl Chloride Hydrochloride is a high-value, multi-functional chemical intermediate essential for advanced synthesis. This compound is particularly significant for introducing the isoquinoline-5-sulfonyl moiety, a key building block in medicinal chemistry and materials science. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides.
• Material Science: Serves as a precursor for creating functional dyes, photoinitiators, and advanced polymers.
• Chemical Biology: Employed in the development of activity-based probes and affinity labels for studying enzyme function.
• Peptide Modification: Acts as a sulfonylation reagent for modifying amino acid side chains in peptide chemistry.
• Academic & Industrial R&D: Fundamental reagent for exploring new organic reactions and synthesizing complex heterocyclic compounds.

Basic Information

Product Name	1-Chloroisoquinoline-5-Sulfonyl Chloride Hydrochloride
CAS No.	105627-81-4
Molecular Formula	C9H6Cl2N2O2S • HCl
Molecular Weight	329.58 g/mol
Synonyms	5-(Chlorosulfonyl)-1-chloroisoquinoline hydrochloride; 1-Chloro-5-chlorosulfonylisoquinoline hydrochloride; Isoquinoline-5-sulfonyl chloride, 1-chloro-, hydrochloride; 1-Chloroisoquinoline-5-sulfonylchloride HCl; 105627-81-4; 1-Chloro-isoquinoline-5-sulfonyl chloride hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Chloroisoquinoline-5-Sulfonyl Chloride Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality ensures reliable performance in your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under anhydrous conditions to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.