Description

Binaltorphimine CAS NO 105618-27-7 is a highly selective and potent κ-opioid receptor (KOR) antagonist. This compound is a critical research tool in neuropharmacology, enabling the study of opioid receptor subtypes and their roles in pain, addiction, and mood disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on central nervous system (CNS) drug discovery and neurochemical pathway analysis.

Application

• Neuroscience Research: A key pharmacological agent for investigating the physiological and behavioral functions of the κ-opioid receptor system.
• Drug Discovery & Development: Used as a reference standard and tool compound in high-throughput screening (HTS) and lead optimization for novel analgesics and neuropsychiatric therapeutics.
• Mechanistic Studies: Employed to elucidate the role of KOR in stress response, depression, anxiety, and substance abuse disorders.
• Biochemical Assays: Serves as a selective ligand in receptor binding assays, autoradiography, and functional cellular assays (e.g., cAMP inhibition, β-arrestin recruitment).
• Preclinical Animal Studies: Used to validate target engagement and assess the in vivo efficacy of potential KOR-targeting drug candidates.

Basic Information

Product Name	Binaltorphimine
CAS No.	105618-27-7
Molecular Formula	C₂₉H₃₈N₄O₆
Molecular Weight	538.64 g/mol
Synonyms	Binaltorphimine; BNI; Binaltorphimine dihydrochloride; 17,17'-Bis(cyclopropylmethyl)-6,6',7,7'-tetrahydro-4,5,4',5'-diepoxy-6,6'-[imino(1,2-ethanediyl)dimino]bis[14-hydroxy-3-methoxymorphinan] dihydrochloride; Nor-Binaltorphimine; Binaltorphimine (BNI); 105618-27-7
EINECS	Contact for details

Quality Control

Our Binaltorphimine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.