Description

Nor-Binaltorphimine Dihydrochloride is a potent and highly selective κ-opioid receptor (KOR) antagonist used extensively in neuroscience and pharmacological research. This compound is critical for studying opioid receptor function, pain pathways, and addiction mechanisms due to its specific receptor blockade. It is an essential research-grade chemical for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on central nervous system (CNS) drug discovery and neurochemical analysis.

Application

• Neuroscience Research: A key tool for investigating the role of κ-opioid receptors in pain modulation, stress response, and mood disorders.
• Pharmacological Studies: Used in in vitro and in vivo assays to determine receptor selectivity, binding affinity, and antagonist potency.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in the development of novel analgesics and treatments for substance abuse.
• Academic & Clinical Research: Facilitates studies on addiction mechanisms, depression, and other CNS-related conditions in university and hospital research settings.
• Biochemical Analysis: Used in receptor autoradiography and other imaging techniques to map receptor distribution in neural tissues.

Basic Information

Product Name	Nor-Binaltorphimine Dihydrochloride
CAS No.	105618-26-6
Molecular Formula	C₂₉H₃₄Cl₂N₄O₄
Molecular Weight	573.51 g/mol
Synonyms	Nor-BNI dihydrochloride; Nor-Binaltorphimine diHCl; 17,17'-Bis(cyclopropylmethyl)-6,6',7,7'-tetradehydro-4,5α:4',5'α-diepoxy-6,6'-imino-7,7'-binorphinan-3,3',14,14'-tetrol dihydrochloride; Nor-BNI; Nor-Binaltorphimine; (5α,7α,8β)-17-(Cyclopropylmethyl)-6,7:8,14-diepoxy-3-hydroxy-4,5-epoxymorphinan-7-methanamine dihydrochloride
EINECS	Contact for details

Quality Control

Our Nor-Binaltorphimine Dihydrochloride is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and NMR, are validated to provide reliable data for scientific decision-making.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.