Description

Cathepsin L Inhibitor I is a potent and selective cell-permeable inhibitor of the cysteine protease Cathepsin L. This compound is a critical research tool for elucidating the role of Cathepsin L in various biological processes, including protein degradation, antigen presentation, and viral entry. It is essential for researchers in pharmaceutical development, biochemistry, and cell biology who require high-purity, reliable chemical probes for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the enzymatic activity and physiological function of Cathepsin L in vitro.
• Cell Biology Studies: Employed in cellular assays to investigate the role of Cathepsin L in processes like apoptosis, autophagy, and extracellular matrix remodeling.
• Drug Discovery & Target Validation: Serves as a key pharmacological tool for validating Cathepsin L as a therapeutic target in diseases such as cancer, osteoporosis, and infectious diseases.
• Virology Research: Applied in studies exploring the involvement of host Cathepsin L in viral processing and entry, particularly for certain coronaviruses and other pathogens.
• Neuroscience Research: Utilized to examine the function of Cathepsin L in neurogenerative conditions and neuronal protein turnover.

Basic Information

Product Name	Cathepsin L Inhibitor I
CAS No.	105608-85-3
Molecular Formula	C₁₈H₁₅N₃O₃S
Molecular Weight	353.40 g/mol
Synonyms	Z-Phe-Tyr(t-Bu)-diazomethyl ketone; Z-FY(t-Bu)-diazomethyl ketone; Cathepsin L Inhibitor Z-FY(t-Bu)DMK; Benzyloxycarbonyl-Phe-Tyr(t-butyl)-diazomethyl ketone; (S)-N-((S)-1-((tert-Butoxycarbonyl)-3-phenylpropanamido)-3-(4-(tert-butyl)phenyl)-1-oxopropan-2-yl)-2-diazoacetamide; Z-FY-CHN2; Cathepsin L Selective Inhibitor I
EINECS	Contact for details

Quality Control

Our Cathepsin L Inhibitor I is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation. A detailed Certificate of Analysis (COA) containing purity, identity, and analytical data is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.