Description

4-Hydroxybevantolol is a key pharmaceutical intermediate and metabolite of the β-adrenergic blocking agent bevantolol. This compound is critical for research and development in cardiovascular pharmacology, particularly in metabolic studies and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug metabolism, pharmacokinetics (PK/PD), and impurity profiling.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis and scale-up of bevantolol and its derivatives.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify metabolites in biological matrices.
• Pharmacology Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways and efficacy of β-blockers.
• Impurity Standard: Serves as a certified reference material (CRM) for quality control, ensuring the purity and safety of the final drug substance.
• Process Development: Employed in the optimization of API manufacturing processes, including route scouting and impurity control.

Basic Information

Product Name	4-Hydroxybevantolol
CAS No.	105566-69-6
Molecular Formula	C20H27NO4
Molecular Weight	345.43 g/mol
Synonyms	1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(4-hydroxyphenoxy)-2-propanol; Bevantolol Hydroxy Metabolite; 4'-Hydroxybevantolol; 1-[2-(3,4-Dimethoxyphenyl)ethylamino]-3-(4-hydroxyphenoxy)-2-propanol; (±)-4'-Hydroxybevantolol
EINECS	Contact for details

Quality Control

Our 4-Hydroxybevantolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.