Description

5-Hydroxy Buspirone is a key pharmaceutical intermediate and active metabolite of the anxiolytic drug buspirone. This compound is critical for research and development in neuropharmacology and for ensuring the quality and efficacy of related therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions focused on central nervous system (CNS) drug development and metabolite studies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis and research of buspirone and its analogs.
• Reference Standard: Used as a high-purity standard in analytical testing (HPLC, LC-MS) for drug substance and product quality control.
• Metabolite Research: Essential for pharmacokinetic and pharmacodynamic studies to understand the metabolism and activity of buspirone.
• Active Pharmaceutical Ingredient (API) Development: Serves as a starting material or intermediate in the development of new CNS-targeting therapeutics.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate serotonin (5-HT1A) receptor interactions.

Basic Information

Product Name	5-Hydroxy Buspirone
CAS No.	105496-33-1
Molecular Formula	C21H31N5O3
Molecular Weight	401.50 g/mol
Synonyms	8-[4-[4-(5-Hydroxypyrimidin-2-yl)piperazin-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione; 5-Hydroxybuspirone; 1H-1,2,4-Triazol-3-amine, 5-hydroxy-4,4-diphenyl-, hydrochloride; Buspirone Metabolite (5-Hydroxy); UNII-2P6K7P8Q4R
EINECS	Contact for details

Quality Control

Our 5-Hydroxy Buspirone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.