Description

Apogossypol Hexaacetate is a synthetic derivative of the natural polyphenol gossypol, characterized by its fully acetylated structure. This chemical modification enhances its stability and solubility profile, making it a valuable intermediate for advanced research and development. It is primarily utilized by pharmaceutical and biotechnology researchers investigating novel therapeutic agents, particularly in the fields of oncology and metabolic disease.

Application

• Pharmaceutical Research Intermediate: Serves as a key synthetic precursor in the development of small-molecule drug candidates targeting Bcl-2 family proteins.
• Oncology Studies: Used in biochemical and cellular assays to study apoptosis (programmed cell death) mechanisms and evaluate anti-cancer activity.
• Chemical Biology Probe: Acts as a tool compound for investigating protein-protein interactions and signaling pathways involved in cell survival.
• Reference Standard: Employed as a high-purity analytical standard in HPLC and LC-MS methods for quality control and metabolic studies.
• Preclinical Development: Utilized in formulation studies and pharmacokinetic profiling during early-stage drug discovery.

Basic Information

Product Name	Apogossypol Hexaacetate
CAS No.	105201-55-6
Molecular Formula	C38H38O10
Molecular Weight	678.70 g/mol
Synonyms	Apogossypol 1,1',2,2',6,6'-Hexaacetate; (±)-Apogossypol Hexaacetate; 1,1',2,2',6,6'-Hexa-O-acetylapogossypol; Gossypol Hexaacetate Derivative; BL-193 Hexaacetate; ApoG2 Hexaacetate; AT-101 Hexaacetate Analog
EINECS	Contact for details

Quality Control

Our Apogossypol Hexaacetate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, suitable for research applications. Quality is verified by advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.