Description

Betamethasone β-D-Glucuronide Sodium Salt is a high-purity, conjugated metabolite of the potent glucocorticoid betamethasone. This compound is of significant value as a critical reference standard and analytical reagent in pharmaceutical research and bioanalytical chemistry. It is primarily needed by research institutions, pharmaceutical companies, and contract testing laboratories engaged in drug metabolism and pharmacokinetic (DMPK) studies, clinical toxicology, and the development of advanced analytical methods.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantification of betamethasone and its metabolites in complex biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for studying the glucuronidation pathway, a major Phase II metabolic route, to understand betamethasone's clearance and bioavailability.
• Clinical & Forensic Toxicology: Used as a calibrator or control in LC-MS/MS and HPLC-UV methods for accurately detecting and quantifying betamethasone exposure in human and animal studies.
• Biomarker Research: Employed in the development of assays to investigate corticosteroid metabolism and its relation to disease states or therapeutic outcomes.
• Method Development & Validation: A key reagent for developing, optimizing, and validating sensitive and specific analytical techniques in regulatory-compliant laboratories.
• Quality Control in Manufacturing: Used to ensure the specificity and accuracy of impurity profiling and assay methods for betamethasone-based pharmaceutical products.

Basic Information

Product Name	Betamethasone β-D-Glucuronide Sodium Salt
CAS No.	105088-07-1
Molecular Formula	C28H37NaO9
Molecular Weight	540.58 g/mol
Synonyms	Betamethasone 17β-D-Glucuronide Sodium Salt; Betamethasone Glucuronide Sodium; 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-(β-D-glucopyranosiduronic acid) Sodium Salt; Sodium Betamethasone Glucuronide; Betamethasone-21-Glucuronide Sodium; BMZ Glucuronide Sodium Salt
EINECS	Contact for details

Quality Control

Our Betamethasone β-D-Glucuronide Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.