Description

4-Aminobenzoic Acid, [14C(U)] is a uniformly carbon-14 labeled isotopologue of para-aminobenzoic acid (PABA), a key biochemical precursor. This radiolabeled compound is essential for conducting detailed metabolic, pharmacokinetic, and environmental fate studies with high sensitivity and traceability. It is primarily utilized by research scientists and process development teams in the pharmaceutical, agrochemical, and life science sectors for advanced tracer applications.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of new chemical entities in preclinical research.
• Biochemical Pathway Analysis: Investigating folate biosynthesis and other metabolic pathways where PABA serves as a vital intermediate.
• Agrochemical Research: Studying the environmental fate, biodegradation, and plant uptake of sulfonamide-based herbicides and other compounds.
• Radioligand Binding Assays: Development of sensitive assays for receptor characterization and screening.
• Synthesis of Labeled Compounds: Serving as a 14C-labeled building block for the synthesis of more complex radiotracers.
• Quality Control & Stability Testing: Use as an internal standard in analytical methods like LC-MS for quantification in complex matrices.

Basic Information

Product Name	4-Aminobenzoic Acid, [14C(U)]
CAS No.	104872-95-9
Molecular Formula	C714C1H7NO2
Molecular Weight	~139.1 (based on 12C average)
Synonyms	Para-Aminobenzoic Acid-14C; PABA-14C; 4-Amino[14C]benzoic Acid; Vitamin Bx-14C; [carboxy-14C]-4-Aminobenzoic Acid; Uniformly Labeled 14C-PABA; Benzoic-14C acid, 4-amino-; 4-Carboxy[14C]aniline
EINECS	Contact for details

Quality Control

Every batch of our 4-Aminobenzoic Acid, [14C(U)] is manufactured and analyzed under strict quality systems to ensure high chemical, radiochemical, and isotopic purity. Comprehensive testing includes HPLC for chemical purity, radio-HPLC or TLC for radiochemical purity, and specific activity determination via Liquid Scintillation Counting (LSC). A detailed Certificate of Analysis (COA), which includes batch-specific data on purity, activity, and solvent composition, is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric moisture. For long-term storage, consider storage at or below -20°C.

Specification

Item	Specification
Appearance	White to Off-White Solid
Identification (IR / NMR)	Conforms to Structure
Chemical Purity (HPLC)	≥ 98.0%
Radiochemical Purity (Radio-HPLC)	≥ 97.0%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (for solutions)	Specified on COA (e.g., Ethanol, Water)
Concentration (for solutions)	Specified on COA (e.g., 0.1 mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.