Description

Methoctramine Tetrahydrochloride Hemihydrate is a selective muscarinic M2 receptor antagonist used extensively in pharmacological research. This compound is critical for studying cholinergic pathways and receptor subtype specificity in various biological systems. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) focused on neuroscience, cardiology, and autonomic nervous system studies.

Application

• Pharmacological Research: As a selective antagonist for investigating the function and distribution of muscarinic M2 receptors.
• Neuroscience Studies: For exploring cholinergic neurotransmission, synaptic plasticity, and cognitive function models.
• Cardiovascular Research: Used to study the role of M2 receptors in heart rate regulation and cardiac muscle response.
• Autonomic Nervous System Analysis: A key tool for dissecting parasympathetic signaling and autonomic control mechanisms.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in screening assays for new therapeutic agents.
• Academic & Teaching Laboratories: Employed in advanced university courses and experimental protocols for molecular pharmacology.

Basic Information

Product Name	Methoctramine Tetrahydrochloride Hemihydrate
CAS No.	104807-46-7
Molecular Formula	C24H44N4O2 • 4HCl • ½H2O
Molecular Weight	566.0 g/mol (hemihydrate form)
Synonyms	Methoctramine tetrahydrochloride; Methoctramine HCl; N,N'-Bis[6-[[(2-methoxyphenyl)methyl]amino]hexyl]-1,8-octanediamine tetrahydrochloride hemihydrate; M2 receptor antagonist; Muscarinic M2 antagonist; AF-DX 116 congener; Pentamethonium derivative; Research compound 104807-46-7
EINECS	Contact for details

Quality Control

Our Methoctramine Tetrahydrochloride Hemihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and verification of water content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmacological and biochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	1.5 - 3.5% (hemihydrate)
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.