Description

4-Chloro-1-Trifluoromethoxy-2-Trifluoromethyl-Benzene is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both trifluoromethoxy and trifluoromethyl substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), improving dielectric anisotropy and thermal stability.
• Organic Electronics: Employed in the synthesis of semiconductors and charge-transport materials for organic light-emitting diodes (OLEDs) and photovoltaic cells.
• Advanced Polymer Chemistry: Acts as a monomer or modifier for creating high-performance, fluorinated polymers with enhanced chemical resistance and low surface energy.
• Chemical Research & Development: A versatile reagent for exploring new reaction pathways in organofluorine chemistry and catalysis.

Basic Information

Product Name	4-Chloro-1-Trifluoromethoxy-2-Trifluoromethyl-Benzene
CAS No.	104678-86-6
Molecular Formula	C9H3ClF6O
Molecular Weight	276.56 g/mol
Synonyms	1-Chloro-4-(trifluoromethoxy)-2-(trifluoromethyl)benzene; 2-Trifluoromethyl-4-chloro-1-trifluoromethoxybenzene; 4-Chloro-α,α,α,α',α',α'-hexafluoro-o-cresol methyl ether; 4-Chloro-2-(trifluoromethyl)phenyl trifluoromethyl ether; Benzene, 1-chloro-4-(trifluoromethoxy)-2-(trifluoromethyl)-; 4-Chloro-1-(trifluoromethoxy)-2-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-1-Trifluoromethoxy-2-Trifluoromethyl-Benzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, with specifications tailored to meet the rigorous demands of process chemistry and scale-up. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with each shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.