Description

Cgs 15943 is a selective adenosine A1 receptor antagonist used in biochemical and pharmacological research. This compound matters for its role in elucidating adenosine receptor signaling pathways and their physiological effects. It is needed by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on neuroscience, cardiology, and metabolic disorders. The product is supplied as a high-purity reference standard under the identifier CAS NO 104615-18-1.

Application

• Neuroscience Research: Investigating the role of adenosine A1 receptors in neurotransmission, neuroprotection, and sleep regulation.
• Cardiovascular Studies: Used as a tool compound to study A1 receptor-mediated effects on heart rate, coronary blood flow, and ischemic preconditioning.
• Metabolic Disorder Research: Exploring adenosine signaling in insulin sensitivity, lipolysis, and other metabolic processes.
• In Vitro Assay Development: Serving as a reference antagonist in high-throughput screening (HTS) and receptor binding assays (e.g., radioligand binding).
• Signal Transduction Pathways: A key pharmacological tool for dissecting downstream effects of adenosine A1 receptor activation or inhibition.
• Preclinical Animal Studies: Administered in research models to validate target engagement and study in vivo efficacy.

Basic Information

Product Name	Cgs 15943
CAS No.	104615-18-1
Molecular Formula	C₁₅H₁₈N₆O
Molecular Weight	298.34 g/mol
Synonyms	9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine; CGS-15943; CGS 15943; 9-Chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine; Adenosine A1 Receptor Antagonist CGS 15943; Triazoloquinazoline Adenosine Antagonist
EINECS	Contact for details

Quality Control

Our Cgs 15943 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound is light-sensitive (store away from light). For long-term storage, consider desiccation to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.