Description

3-Pyridinecarbonyl Chloride, 4-(Trifluoromethyl)- (9Ci) is a high-value, reactive heterocyclic building block. This compound is essential for introducing the 4-(trifluoromethyl)pyridine-3-carbonyl moiety into target molecules, a key structural motif in modern chemical synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients. Its utility extends to advanced material science for the development of specialty polymers and ligands.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethylpyridine group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a key starting material for constructing sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical manufacturers offering bespoke synthesis services for complex molecules.

Basic Information

Product Name	3-Pyridinecarbonyl Chloride, 4-(Trifluoromethyl)- (9Ci)
CAS No.	104326-73-0
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	4-(Trifluoromethyl)nicotinoyl chloride; 4-(Trifluoromethyl)pyridine-3-carbonyl chloride; 3-Carbonyl chloride-4-(trifluoromethyl)pyridine; 4-Trifluoromethylnicotinic acid chloride; 4-Trifluoromethyl-3-pyridinecarbonyl chloride; 3-Pyridinecarbonyl chloride, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)nicotinic acid chloride
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarbonyl Chloride, 4-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and reactive acid chloride nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.