Description

10-Hydroxy-9-Nitrocamptothecin is a chemically modified derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is of significant interest for its potential to enhance therapeutic efficacy and modulate the pharmacokinetic profile of the parent molecule. It is primarily utilized by pharmaceutical researchers and developers in the fields of oncology and medicinal chemistry for the synthesis of novel anticancer agents and as a key intermediate in drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel camptothecin-based anticancer drugs and prodrugs.
• Oncology Research: Used as a reference standard and active compound in biochemical and cellular assays to study topoisomerase I inhibition and apoptosis.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop derivatives with improved solubility, stability, and targeted delivery.
• Preclinical Development: Acts as a key material for formulation studies, pharmacokinetic profiling, and efficacy testing in animal models.
• Academic Research: Utilized in university and institutional labs for fundamental research on DNA damage and repair mechanisms.
• Bioconjugate Synthesis: A potential candidate for conjugation with antibodies, polymers, or nanoparticles to create targeted cancer therapies.

Basic Information

Product Name	10-Hydroxy-9-Nitrocamptothecin
CAS No.	104267-73-4
Molecular Formula	C20H15N3O6
Molecular Weight	393.35 g/mol
Synonyms	9-Nitro-10-hydroxycamptothecin; 10-Hydroxy-9-nitro-20(S)-camptothecin; (S)-10-Hydroxy-9-nitrocamptothecin; 9-Nitro-10-HCT; Camptothecin, 10-hydroxy-9-nitro-; 20(S)-10-Hydroxy-9-nitrocamptothecin
EINECS	Contact for details

Quality Control

Our 10-Hydroxy-9-Nitrocamptothecin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the (S)-configuration, and identity confirmation via spectroscopic methods. We provide Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Custom synthesis to meet specific purity or packaging requirements is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent condensation. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% (S-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.