Description

Carbocyclic Puromycin is a potent, structurally modified analog of the classic protein synthesis inhibitor puromycin, distinguished by its carbocyclic sugar moiety. This modification enhances its metabolic stability and makes it a critical research tool for studying ribosome function, translation termination, and cellular apoptosis pathways. It is primarily utilized by pharmaceutical researchers, academic biochemists, and biotechnology companies engaged in molecular biology and anticancer drug discovery.

Application

• Biochemical Research: As a selective and irreversible inhibitor of protein synthesis in eukaryotic cells for mechanistic studies.
• Cell Biology: Induction of apoptosis in cell culture models to study programmed cell death and screen for protective compounds.
• Antibiotic Mechanism Studies: Investigation of ribosome structure, function, and the peptidyl transferase center.
• Molecular Probe Development: Serving as a scaffold for developing novel probes to label and monitor active translation sites.
• Oncology Research: Evaluation in preclinical studies for its cytotoxic properties against various cancer cell lines.
• Virology: Used to inhibit host cell protein synthesis in studies of viral replication and host-pathogen interactions.

Basic Information

Product Name	Carbocyclic Puromycin
CAS No.	104264-92-8
Molecular Formula	C22H29N7O5
Molecular Weight	471.51 g/mol
Synonyms	Carbocyclic Puromycin Dihydrochloride; 3'-Deoxy-3'-(L-phenylalanylamino)carbocyclic Puromycin; NSC 36395; (1S,2R,3S,4R)-4-{6-Amino-9H-purin-9-yl}-2-({(2S)-2-amino-3-phenylpropanoyl}amino)-3-hydroxycyclopentane-1-carboxylic acid; 3'-Deoxy-3'-(L-phenylalanylamino)carbapromycin; Puromycin, carbocyclic analog
EINECS	Contact for details

Quality Control

Our Carbocyclic Puromycin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%
Biological Activity	Tested in cell-based assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.