Description

Rubitecan is a synthetic camptothecin derivative and a potent topoisomerase I inhibitor. This compound is of significant interest in pharmaceutical research and development due to its mechanism of action, which interferes with DNA replication in rapidly dividing cells. It is primarily utilized by researchers and developers in the oncology and life sciences sectors for the investigation and formulation of novel chemotherapeutic agents.

Application

• Oncology Research: As a key intermediate or active pharmaceutical ingredient (API) in preclinical and clinical research for various cancer types.
• Pharmaceutical Development: For the formulation and development of injectable or oral anti-cancer drug candidates.
• Biochemical Studies: Used as a specific tool compound in molecular biology to study topoisomerase I inhibition and DNA damage mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Academic Research: Employed in university and institutional labs for fundamental cancer biology and medicinal chemistry studies.

Basic Information

Product Name	Rubitecan
CAS No.	104195-61-1
Molecular Formula	C₂₃H₂₃N₃O₅
Molecular Weight	421.45 g/mol
Synonyms	9-Nitro-20(S)-camptothecin; 9-Nitro-20(S)-camptothecine; RFS 2000; NSC 628503; (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-nitro-; 9-Nitrocamptothecin; Rubitecanum
EINECS	Contact for details

Quality Control

Our Rubitecan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development purposes. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange-yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.