Description

10,11-Methylenedioxy-20-Camptothecin is a semi-synthetic derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is of significant interest for its enhanced stability and potential therapeutic profile compared to its parent molecule. It serves as a critical pharmaceutical intermediate and reference standard in oncology research and drug development for cancer treatments.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel anticancer agents and prodrugs.
• Research & Development: Used as a reference standard and active compound in preclinical studies targeting topoisomerase I.
• Biochemical Research: Tool compound for studying cell cycle arrest, apoptosis, and DNA damage mechanisms.
• Anticancer Drug Discovery: Core scaffold for developing new chemotherapeutic candidates with improved solubility and reduced toxicity.
• Analytical Standard: High-purity material for HPLC, LC-MS, and NMR method development and validation in quality control laboratories.

Basic Information

Item	Detail
Product Name	10,11-Methylenedioxy-20-Camptothecin
CAS No.	104155-89-7
Molecular Formula	C₂₂H₁₆N₂O₅
Molecular Weight	388.37 g/mol
Synonyms	10,11-Methylenedioxycamptothecin; 20-Camptothecin, 10,11-methylenedioxy-; MDC; 10,11-(Methylenedioxy)camptothecin; Camptothecin, 10,11-methylenedioxy-; (S)-10,11-Methylenedioxycamptothecin; (19S)-10,11-Methylenedioxy-20-camptothecin
EINECS	Contact for details

Quality Control

Our 10,11-Methylenedioxy-20-Camptothecin is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. All products are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request. We adhere to cGMP guidelines where applicable to support pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.