Description

3-(Trifluoromethyl) Pyridine-2-Sulfonyl Chloride is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in the reactive sulfonyl chloride group, which enables efficient introduction of the sulfonamide moiety, a key pharmacophore in modern drug discovery. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor for synthesizing sulfonamide-based drug candidates, including kinase inhibitors, receptor antagonists, and antimicrobial agents.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethylpyridine scaffold enhances biological activity and metabolic stability.
• Material Science: Serves as a building block for creating functionalized polymers, liquid crystals, and advanced materials with specific electronic or surface properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for activity-based protein profiling (ABPP) and the design of covalent enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production under cGMP for clinical trial materials.

Basic Information

Product Name	3-(Trifluoromethyl) Pyridine-2-Sulfonyl Chloride
CAS No.	104040-75-7
Molecular Formula	C6H3ClF3NO2S
Molecular Weight	245.61 g/mol
Synonyms	2-Pyridinesulfonyl chloride, 3-(trifluoromethyl)-; 3-(Trifluoromethyl)-2-pyridinesulfonyl chloride; 3-Trifluoromethylpyridine-2-sulfonyl chloride; 2-Pyridinesulfonyl chloride, 3-(trifluoromethyl)-; 3-CF3-Pyridine-2-SO2Cl; 3-Trifluoromethyl-2-pyridylsulfonyl chloride; 3-(Trifluoromethyl)picolinoyl chloride (common misnomer); 3-TFM-Py-2-SO2Cl
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl) Pyridine-2-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.