Description

Halichondrin B is a complex, macrocyclic polyether natural product originally isolated from marine sponges. This compound is of profound interest due to its potent and selective antitumor activity, serving as the foundational chemical scaffold for the development of novel chemotherapeutic agents. It is a critical reference standard and advanced intermediate for pharmaceutical research and development, particularly in oncology and drug discovery programs targeting microtubule dynamics.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for the identification, assay, and impurity profiling of related drug substances and metabolites.
• Oncology Drug Discovery: Serves as the lead compound and synthetic target for developing novel anticancer therapeutics, such as the derivative Eribulin mesylate.
• Biochemical Research: Employed in studies investigating mechanisms of microtubule inhibition, cell cycle arrest, and apoptosis induction in cancer cell lines.
• Process Chemistry & Synthesis: Acts as a key intermediate or target molecule in complex total synthesis projects and route development for scale-up.
• Academic Research: Utilized in universities and research institutes for pharmacological studies and exploring structure-activity relationships (SAR) of marine natural products.

Basic Information

Product Name	Halichondrin B
CAS No.	103614-76-2
Molecular Formula	C60H86O19
Molecular Weight	1111.31 g/mol
Synonyms	Halichondrin B; Halichondrin-B; NSC 609395; Eribulin Intermediate; Norhalichondrin B Homolog; Macrocyclic Ketone from *Halichondria okadai*; (1R,4S,6R,7S,8S,11S,12S,14R,16S,19S,20R,22S,23S,25R,28S,30S,32R,34S,35R,36S,38R,39S,41R,43S,44R,46S,47S,49R,51S,53R,54S,56S,57S,59R,61S,63R,64S,66S,67S,69R,71S,73R,74S,76S,77S,79R,81S,83R,84S,86S,87S,89R,91S,93R,94S,96S,97S,99R,101S,103R,104S,106S,107S,109R,111S,113R,114S,116S,117S,119R)-4,6,7,8,11,12,14,16,19,20,22,23,25,28,30,32,34,35,36,38,39,41,43,44,46,47,49,51,53,54,56,57,59,61,63,64,66,67,69,71,73,74,76,77,79,81,83,84,86,87,89,91,93,94,96,97,99,101,103,104,106,107,109,111,113,114,116,117,119-Hexacontahydro-1,14,25,30,41,53,59,73,84,99,109,119-dodecamethyl-8,23,47,57,77,87,107,117-octaoxa-2,15,26,31,42,54,60,74,85,100,110,120-dodecaoxadodecacyclo[97.25.0.0³,¹¹⁷.0⁵,¹⁰.0¹³,²⁴.0¹⁵,²².0²⁷,³⁹.0²⁹,³⁸.0³³,³⁷.0⁴³,⁵².0⁴⁵,⁵¹.0⁴⁸,⁵⁰.0⁵⁵,⁶⁶.0⁵⁸,⁶⁵.0⁶²,⁶⁴.0⁶⁸,⁷⁹.0⁷⁰,⁷⁸.0⁷²,⁷⁷.0⁸⁰,⁹⁴.0⁸²,⁹³.0⁸⁵,⁹².0⁸⁸,¹⁰⁶.0⁹⁰,¹⁰⁵.0⁹⁵,¹⁰⁴.0⁹⁸,¹⁰³.0¹⁰²,¹⁰¹]henicosaoxapentacontaphane-120,122,124,126,128,130,132,134,136,138,140,142-dodecaone
EINECS	Contact for details

Quality Control

Our Halichondrin B is produced and handled under strict quality management systems suitable for research and development use. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided, documenting batch-specific results for purity, related substances, and other critical parameters to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in DMSO, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.