Description

Boc-Val-Cmk CAS NO 103542-47-8 is a specialized, high-purity chemical building block and protease inhibitor used in advanced biochemical research and pharmaceutical development. This compound is critical for studying enzyme mechanisms and for the synthesis of peptide-based therapeutics and diagnostic agents. It is primarily utilized by research scientists, process chemists, and manufacturers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Biochemical Research: Acts as a potent, irreversible inhibitor of cysteine proteases (e.g., cathepsins, caspases) for mechanistic studies and enzyme characterization.
• Pharmaceutical Development: Serves as a key intermediate in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Proteomics & Cell Biology: Used to selectively inhibit specific proteolytic pathways to study protein function, apoptosis, and cellular signaling.
• Diagnostic Reagent Synthesis: Employed in the creation of specialized probes and reagents for diagnostic assays and imaging.
• Peptide Chemistry: Functions as a protected valine derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Academic Research: A valuable tool in university and institutional labs for fundamental research in enzymology and medicinal chemistry.

Basic Information

Product Name	Boc-Val-Cmk
CAS No.	103542-47-8
Molecular Formula	C17H23ClN2O5
Molecular Weight	370.83 g/mol
Synonyms	Boc-Valine Chloromethyl Ketone; N-(tert-Butoxycarbonyl)-L-valyl chloromethane; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylbutyl chloromethyl ketone; Boc-L-Val-CH2Cl; Boc-Val-CH2Cl; tert-Butoxycarbonylvalyl chloromethyl ketone; Fmoc-Val-Cmk (related protected form); L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-, chloromethyl ketone
EINECS	Contact for details

Quality Control

Our Boc-Val-Cmk is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.