Description

(4-Fluoro-Phenyl)-Methanesulfonyl Chloride is a high-purity organosulfur building block and key electrophilic reagent. This compound matters for its critical role as a versatile sulfonylation agent in advanced organic synthesis, enabling the introduction of the (4-fluorophenyl)methanesulfonyl moiety. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular entities and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorophenylsulfonyl group modulates biological activity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialized polymers and advanced functional materials.
• Chemical Biology Probe Development: Employed to create sulfonamide-based probes and inhibitors for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates for clients.
• Sulfonamide Library Synthesis: Facilitates high-throughput parallel synthesis for medicinal chemistry campaigns aimed at generating diverse sulfonamide compound libraries.

Basic Information

Item	Detail
Product Name	(4-Fluoro-Phenyl)-Methanesulfonyl Chloride
CAS No.	103360-04-9
Molecular Formula	C7H6ClFO2S
Molecular Weight	208.64 g/mol
Synonyms	4-Fluorophenylmethanesulfonyl chloride; 1-(Chlorosulfonylmethyl)-4-fluorobenzene; p-Fluorobenzylsulfonyl chloride; (4-Fluorobenzyl)sulfonyl chloride; 4-Fluorobenzylsulfonyl chloride; α-Chlorosulfonyl-4-fluorotoluene; (p-Fluorophenyl)methanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our (4-Fluoro-Phenyl)-Methanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data (HPLC, GC, NMR) are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.