Description

3-(1,3-Dioxolan-2-Yl)Thiophene-2-Sulfonyl Chloride is a specialized sulfonyl chloride derivative, a high-value synthetic intermediate prized for its reactive sulfonyl chloride group and protected aldehyde functionality. This compound matters for its critical role in constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced organic materials. Pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers need this building block for its versatility in nucleophilic substitution reactions, enabling the introduction of sulfonamide moieties under mild conditions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for creating sulfonamide-based therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate sulfonamide functional groups.
• Material Science Research: Employed in the creation of functional polymers, ligands for catalysis, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Serves as a reactive handle for bioconjugation and the development of activity-based probes targeting specific enzymes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.
• Academic & R&D Laboratories: Utilized in methodological development and exploratory chemistry for new reaction pathways involving heterocyclic sulfonyl chlorides.

Basic Information

Product Name	3-(1,3-Dioxolan-2-Yl)Thiophene-2-Sulfonyl Chloride
CAS No.	103011-38-7
Molecular Formula	C7H7ClO4S2
Molecular Weight	254.71 g/mol
Synonyms	2-Thiophenesulfonyl chloride, 3-(1,3-dioxolan-2-yl)-; 3-(1,3-Dioxolan-2-yl)thiophene-2-sulfonyl chloride; 3-(2,2-Dimethyl-1,3-dioxolan-4-yl)thiophene-2-sulfonyl chloride (related protected form); Thiophene-2-sulfonyl chloride, 3-(1,3-dioxolan-2-yl)-; 3-(1,3-Dioxolan-2-yl)-2-thiophenesulfonyl chloride; 2-(1,3-Dioxolan-2-yl)thiophene-5-sulfonyl chloride (alternative numbering); Sulfonyl chloride thiophene dioxolane derivative
EINECS	Contact for details

Quality Control

Our 3-(1,3-Dioxolan-2-Yl)Thiophene-2-Sulfonyl Chloride is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.