Description

2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride is a high-purity, specialized organosulfur reagent featuring a reactive sulfonyl chloride group and a trifluoromethoxy substituent. This compound is a critical building block in advanced organic synthesis, enabling the introduction of the sulfonamide moiety under mild conditions. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where the trifluoromethoxy group is desired to modulate lipophilicity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including protease inhibitors, kinase inhibitors, and antibacterial agents.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the sulfonamide functional group contributes to biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Chemical Biology & Proteomics: Employed as an activity-based probe or labeling reagent for studying enzyme activity and protein interactions.
• Custom Synthesis & Contract Manufacturing: An essential reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride
CAS No.	103008-51-1
Molecular Formula	C7H4ClF3O3S
Molecular Weight	260.62 g/mol
Synonyms	2-(Trifluoromethoxy)benzenesulfonyl chloride; o-(Trifluoromethoxy)benzenesulfonyl chloride; 1-(Trifluoromethoxy)benzene-2-sulfonyl chloride; 2-Trifluoromethoxybenzenesulfonyl chloride; (2-Trifluoromethoxyphenyl)sulfonyl chloride; α,α,α-Trifluoro-o-anisylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.