Description

1-Methylamsacrine is a synthetic derivative of the antineoplastic agent amsacrine, representing a key intermediate in pharmaceutical research and development. This compound is of significant interest for its potential role in the study and synthesis of novel chemotherapeutic agents targeting DNA topoisomerase II. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery, preclinical studies, and the development of advanced therapeutic formulations.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential anticancer drug candidates.
• Biochemical Research: Used as a reference standard or active compound in studies investigating topoisomerase II inhibition mechanisms.
• Oncology R&D: Employed in preclinical research for evaluating the efficacy and structure-activity relationships (SAR) of amsacrine analogs.
• Academic Studies: Utilized in university and institutional laboratories for chemical biology and medicinal chemistry projects.
• API Development: Acts as a precursor in the development and scale-up processes for Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	1-Methylamsacrine
CAS No.	102941-25-3
Molecular Formula	C₁₅H₁₅N₃O
Molecular Weight	253.30 g/mol
Synonyms	N-[4-(Acridin-9-ylamino)-3-methoxyphenyl]-N-methylmethanesulfonamide; 1-Methyl-amsacrine; 9-[[2-Methoxy-4-[(methylsulfonyl)amino]phenyl]amino]acridine; Amsacrine, 1-methyl-; Methanesulfonamide, N-[4-(9-acridinylamino)-3-methoxyphenyl]-N-methyl-
EINECS	Contact for details

Quality Control

Our 1-Methylamsacrine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.