Description

4-Hydroxyandrostenedione Glucuronide is a key conjugated metabolite of the aromatase inhibitor 4-hydroxyandrostenedione (formestane). This compound matters for researchers and developers as it provides a critical reference standard for analytical and pharmacokinetic studies in steroid metabolism and anti-cancer drug development. It is primarily needed by pharmaceutical R&D laboratories, clinical research organizations, and manufacturers of diagnostic kits for hormone analysis.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of formestane metabolites in biological matrices during drug development and clinical trials.
• Metabolite Research: Used in studies investigating the metabolic pathways, pharmacokinetics, and excretion profiles of aromatase inhibitors.
• Clinical Diagnostics: Employed as a calibrator or control in the development and validation of LC-MS/MS or immunoassay methods for steroid hormone profiling.
• Biochemical Research: A tool for studying glucuronidation enzymes (UGTs) and the phase II metabolism of steroidal compounds.
• Anti-Cancer Drug Development: Supports research into the efficacy and safety profile of aromatase inhibitors used in hormone-dependent cancer therapies.
• Regulatory Compliance: Essential for conducting bioanalytical method validation as per FDA, EMA, and ICH guidelines for new drug applications.

Basic Information

Product Name	4-Hydroxyandrostenedione Glucuronide
CAS No.	102848-54-4
Molecular Formula	C25H36O9
Molecular Weight	480.55 g/mol
Synonyms	4-Hydroxyandrost-4-ene-3,17-dione Glucuronide; Formestane Glucuronide; 4-OHA Glucuronide; 4-Hydroxyandrostenedione 17β-D-Glucuronide; Androst-4-ene-4-hydroxy-3,17-dione glucuronide; 4-Hydroxyandrost-4-ene-3,17-dione 17-glucuronide; NSC 331095; 4-Hydroxyandrostenedione 17-Glucuronide
EINECS	Contact for details

Quality Control

Our 4-Hydroxyandrostenedione Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research and reference material applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at -20°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.