Description

Mannostatin B CAS NO 102822-66-2 is a specialized biochemical compound, a potent and specific inhibitor of α-mannosidase enzymes. This activity makes it a critical tool for researchers investigating glycoprotein processing, lysosomal storage disorders, and carbohydrate-mediated biological pathways. It is primarily utilized by pharmaceutical R&D teams, academic biochemistry laboratories, and biotechnology companies focused on glycoscience and drug discovery for metabolic diseases.

Application

• Glycobiology Research: As a selective inhibitor to study N-linked oligosaccharide processing and the role of specific α-mannosidases in cellular systems.
• Enzyme Mechanism Studies: Used in kinetic and structural studies to elucidate the function and inhibition of Class I and II α-mannosidases.
• Lysosomal Storage Disorder Models: Employed in vitro to induce and model biochemical phenotypes related to α-mannosidosis for therapeutic screening.
• Cancer Research: Investigation of altered glycosylation patterns in tumor cells and the impact of mannosidase inhibition on cell adhesion and signaling.
• Virology Studies: Research into viral envelope glycoprotein maturation and the role of host cell mannosidases in infectivity.
• Plant Biochemistry: Study of plant glycan biosynthesis and the effect of mannosidase inhibitors on plant development.

Basic Information

Product Name	Mannostatin B
CAS No.	102822-66-2
Molecular Formula	C7H14N2O4S
Molecular Weight	222.26 g/mol
Synonyms	1,4-Dideoxy-1,4-imino-D-mannitol S-oxide; Mannostatin B; (2R,3R,4R,5S)-1,6-Bis(ethylamino)-1,6-dideoxy-2,3,4,5-tetrahydroxyhexane 1-oxide; α-Mannosidase Inhibitor; DIMSO; 1,4-Dideoxy-1,4-imino-D-mannitol 1-oxide
EINECS	Contact for details

Quality Control

Our Mannostatin B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and specific rotation verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Specific Rotation	[α]²⁰D: +75° to +85° (c=1 in H₂O)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.