Description

Mannostatin A, Hydrochloride is a potent and specific inhibitor of α-mannosidase enzymes, a key compound for glycobiology research and drug discovery. Its primary value lies in its ability to disrupt N-linked glycan processing, making it an essential tool for studying glycosylation pathways and their role in cellular functions and disease states. This product is critical for researchers and developers in pharmaceutical R&D, biotechnology, and academic laboratories focused on metabolic disorders, cancer biology, and the development of glycosidase-targeted therapeutics.

Application

• Glycobiology Research: Used as a specific biochemical tool to inhibit Golgi α-mannosidase I and II, enabling the study of N-linked oligosaccharide biosynthesis and processing.
• Drug Discovery & Screening: Serves as a reference standard and pharmacologic agent in high-throughput screens for novel glycosidase inhibitors targeting diseases like cancer and viral infections.
• Metabolic Pathway Analysis: Employed to induce and study endoplasmic reticulum-associated degradation (ERAD) and unfolded protein response (UPR) by disrupting proper glycoprotein folding.
• Cell Biology Studies: Applied to investigate the role of protein glycosylation in cell adhesion, signaling, and immune response modulation.
• Biochemical Assay Development: Utilized as a key component in enzymatic assays to measure α-mannosidase activity and for the calibration of analytical methods.
• Standards & Controls: Provides a high-purity certified reference material for quality control in the production of other biochemical reagents and for analytical method validation (HPLC, MS).

Basic Information

Product Name	Mannostatin A, Hydrochloride
CAS No.	102822-56-0
Molecular Formula	C7H15ClN2O4
Molecular Weight	226.66 g/mol
Synonyms	Mannostatin A HCl; (2R,5R,6S)-5-(Aminomethyl)-2-(hydroxymethyl)-6-(1H-imidazol-5-yl)tetrahydro-2H-pyran-3-ol hydrochloride; α-Mannosidase Inhibitor; 1,4-Dideoxy-1,4-imino-D-mannitol hydrochloride derivative; Golgi α-Mannosidase II Inhibitor; 5-Amino-1,5-dideoxy-1,5-imino-D-mannitol hydrochloride; MDL 25,637
EINECS	Contact for details

Quality Control

Our Mannostatin A, Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis. A detailed Certificate of Analysis (COA) providing full specifications and test results is supplied with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.