Description

Cyclosporin A Analog B-5-49 is a synthetic derivative of the potent immunosuppressive agent Cyclosporin A, identified by CAS NO 102819-70-5. This analog is engineered for research applications, offering a modified pharmacological profile to study structure-activity relationships and explore new therapeutic pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on immunology, transplant medicine, and autoimmune disease research.

Application

• Immunosuppressive Research: A key reference compound for investigating the mechanism of action of calcineurin inhibitors and T-cell activation pathways.
• Structure-Activity Relationship (SAR) Studies: Used to map the critical functional groups of cyclosporine required for biological activity and binding affinity.
• Drug Discovery & Development: Serves as a lead compound or intermediate in the synthesis of novel immunosuppressive agents with potentially improved efficacy or reduced toxicity profiles.
• Biochemical Assay Development: Employed as a standard or control in high-throughput screening (HTS) assays targeting cyclophilin and calcineurin.
• Academic & Preclinical Research: Facilitates fundamental studies in immunology, organ transplantation models, and autoimmune disorders.

Basic Information

Product Name	Cyclosporin A Analog B-5-49
CAS No.	102819-70-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cyclosporin A Derivative B-5-49; Cyclosporine A Analog B-5-49; CsA Analog B-5-49; [D-Ser]⁸-Cyclosporin A Analog; Cyclosporin Derivative 102819-70-5; Immunosuppressant Analog B-5-49
EINECS	Contact for details

Quality Control

Our Cyclosporin A Analog B-5-49 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.