Description

(S)-n-Deacetyl Colchicine D-10-Camphorsulfonate is a high-purity, chiral derivative of the natural alkaloid colchicine, specifically modified with a camphorsulfonate salt group. This compound is of significant value in pharmaceutical research and development, particularly as a key intermediate or reference standard in the synthesis of novel therapeutic agents. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers focused on anti-inflammatory drug discovery, gout treatment research, and tubulin polymerization studies.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of advanced colchicine analogs and prodrugs with targeted therapeutic profiles.
• Biochemical Research: Used as a reference standard or active agent in studies investigating microtubule dynamics, cell cycle arrest, and anti-mitotic mechanisms.
• Anti-inflammatory Drug Development: Employed in preclinical research for developing new treatments for acute gout flares, familial Mediterranean fever, and other inflammatory conditions.
• Analytical Standard: Provides a high-purity benchmark for quality control and method development in analytical laboratories using HPLC, LC-MS, or NMR.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of colchicine-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(S)-n-Deacetyl Colchicine D-10-Camphorsulfonate
CAS No.	102419-98-7
Molecular Formula	C₃₄H₄₃NO₁₀S
Molecular Weight	657.78 g/mol
Synonyms	(S)-N-Deacetylcolchicine 10-Camphorsulfonate; Colchiceine Camphorsulfonate; (S)-Deacetylcolchicine Camphorsulfonic Acid Salt; (7S)-N-Deacetyl-N-(10-camphorsulfonyl)colchicine; (S)-Colchiceine 10-Camphorsulfonate Ester; D-10-Camphorsulfonylcolchiceine; (S)-Deacetylcolchicine D-Camphor-10-sulfonate
EINECS	Contact for details

Quality Control

Our (S)-n-Deacetyl Colchicine D-10-Camphorsulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.