Description

n-Desmethyl Trimeprazine Sulfoxide is a key pharmaceutical intermediate and metabolite of the phenothiazine derivative, trimeprazine. This compound is of significant value in analytical chemistry and drug development for its role in pharmacokinetic studies, metabolic pathway elucidation, and as a reference standard. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of analytical standards and reagents for use in HPLC, LC-MS, and other chromatographic applications.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and qualification of trimeprazine and its metabolites in biological matrices.
• Metabolite Studies: Critical for in-vitro and in-vivo ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the metabolic fate of trimeprazine.
• Analytical Method Development: Used as a precise calibrant in developing and validating HPLC, UPLC, and LC-MS/MS methods for forensic, clinical, and pharmaceutical analysis.
• Impurity Profiling: Employed as an identified impurity standard to monitor and control the quality of active pharmaceutical ingredients (APIs) during manufacturing.
• Pharmacology Research: Utilized in preclinical studies to investigate the structure-activity relationships (SAR) and pharmacological effects of phenothiazine derivatives.

Basic Information

Product Name	n-Desmethyl Trimeprazine Sulfoxide
CAS No.	102416-02-4
Molecular Formula	C₁₇H₂₀N₂OS
Molecular Weight	300.42 g/mol
Synonyms	10-(3-Dimethylamino-2-methylpropyl)-2-(methylsulfinyl)phenothiazine; Desmethyltrimeprazine Sulfoxide; Trimeprazine Sulfoxide N-Desmethyl Metabolite; 2-Methyl-3-(2-methyl-10H-phenothiazin-10-yl)propyl]dimethylamine S-Oxide; Alimemazine Sulfoxide Desmethyl; N-Desmethyl-Alimemazine Sulfoxide; 10H-Phenothiazine-10-propanamine, N,N,2-trimethyl-, 5-oxide
EINECS	Contact for details

Quality Control

Our n-Desmethyl Trimeprazine Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity assessment by HPLC, and determination of residual solvents and impurities to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.