Description

Jasplakinolide is a potent and cell-permeable macrocyclic depsipeptide that acts as a highly specific stabilizer of actin filaments. This compound is a critical research tool for studying cytoskeletal dynamics, cell motility, and morphology in live cells. It is essential for researchers in cell biology, pharmacology, and neuroscience who require precise chemical probes to investigate actin polymerization and related cellular processes. Jasplakinolide CAS NO 102396-24-7 is supplied to meet the stringent purity requirements of advanced life science research.

Application

• Cytoskeleton Research: Used as a potent inducer of actin polymerization and stabilization in live cell imaging and biochemical assays.
• Cell Biology Studies: A key pharmacological tool for investigating cell adhesion, migration, and morphological changes driven by the actin cytoskeleton.
• Mechanism of Action Studies: Employed to study the effects of actin stabilization on various cellular pathways, including apoptosis and signal transduction.
• Neuroscience Research: Utilized to examine the role of actin dynamics in neuronal growth cone guidance, synapse formation, and plasticity.
• Drug Discovery Screening: Serves as a reference compound and positive control in high-content screening assays targeting the cytoskeleton.
• Marine Natural Product Research: Studied for its origin as a bioactive metabolite from marine sponges and its potential pharmacological activities.

Basic Information

Product Name	Jasplakinolide
CAS No.	102396-24-7
Molecular Formula	C₃₆H₄₅BrN₄O₆
Molecular Weight	697.67 g/mol
Synonyms	Jaspamide; JAS; L-Jasplakinolide; NSC 613009; (3S,6S,9S,12R,15S,18S,21S,24S,30S)-30-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]-12-(3-bromo-4-hydroxyphenyl)-6,9,21,24-tetraisobutyl-3,15-diisopropyl-2,5,8,11,14,17,20,23,28-nonaoxo-18-(1H-indol-3-ylmethyl)-1,4,7,10,13,16,19,22,27-nonaazacyclotriacontane-30-carboxylic acid
EINECS	Contact for details

Quality Control

Our Jasplakinolide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.