Description

Boc-Leu-Chloromethylketone is a specialized protected amino acid derivative, specifically a chloromethyl ketone functionalized with a tert-butoxycarbonyl (Boc) protecting group on the leucine residue. This compound serves as a crucial irreversible protease inhibitor and a key intermediate in peptide synthesis and biochemical research. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on enzymology and drug discovery.

Application

• Protease Inhibition Studies: Acts as an irreversible active-site directed inhibitor for serine and cysteine proteases, essential for studying enzyme mechanisms.
• Biochemical Research Reagent: Used in the development of enzyme assays and the investigation of proteolytic pathways.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of peptide-based drug candidates and therapeutic agents.
• Proteomics & Cell Biology: Employed to control specific protease activity in cell lysates and complex biological samples.
• Chemical Biology Tool: Utilized for affinity labeling and mapping the active sites of target enzymes.

Basic Information

Product Name	Boc-Leu-Chloromethylketone
CAS No.	102123-85-3
Molecular Formula	C₁₂H₂₂ClNO₄
Molecular Weight	279.76 g/mol
Synonyms	Boc-Leu-CH₂Cl; N-(tert-Butoxycarbonyl)-L-leucine chloromethyl ketone; (S)-1-((tert-Butoxycarbonyl)amino)-4-methyl-1-oxopentan-2-yl chloromethanone; BOC-L-Leucine chloromethyl ketone; N-Boc-L-leucine chloromethyl ketone; L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, chloromethyl ketone; Protease Inhibitor (Leu-based)
EINECS	Contact for details

Quality Control

Our Boc-Leu-Chloromethylketone is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.