Description

21-Hydroxyoligomycin A is a chemically modified derivative of the potent mitochondrial ATP synthase inhibitor, Oligomycin A. This compound is of significant interest in biochemical and pharmacological research for its specific inhibitory activity, which is crucial for studying cellular energy metabolism and related pathways. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in metabolic studies, target validation, and the development of novel therapeutic agents.

Application

• Biochemical Research: A key tool for investigating mitochondrial function, oxidative phosphorylation, and ATP synthesis mechanisms in cellular models.
• Pharmacology & Drug Discovery: Used in target identification and validation studies for diseases linked to metabolic dysregulation, such as cancer and certain genetic disorders.
• Cell Biology Studies: Employed to induce metabolic stress and study cellular responses, including apoptosis, autophagy, and signal transduction pathways.
• Antifungal Research: Serves as a reference compound in studies exploring the mechanism of action of polyene macrolide antibiotics and for developing new antifungal agents.
• Academic & Industrial R&D: Essential for basic science and applied research in universities, contract research organizations (CROs), and biopharma R&D departments.

Basic Information

Product Name	21-Hydroxyoligomycin A
CAS No.	102042-09-1
Molecular Formula	C46H76O12
Molecular Weight	821.1 g/mol
Synonyms	21-Hydroxy-oligomycin A; Oligomycin A, 21-hydroxy-; 21-OH-Oligomycin A; Oligomycin A 21-hydroxy derivative; (3R,4S,5S,8R,9S,10S,13R,15S,17R,18S,19S,21R,23S,24S,25S,28S,29S,30R,31S,32S,33S,34S,35S,36S,37S,38S,39S,40S,41S,42S,43S,44S,45S,46S)-21-Hydroxy-46-[(1S)-1-hydroxyethyl]-33,34,35,36,37,38,39,40,41,42,43,44,45,46-tetradecahydro-3,4:15,16:23,24:28,29-tetrakis(epoxy)-10,13,18-trimethyl-14,39-dioxapentacyclo[33.3.1.15,8.117,32.125,28]hexatetracontane-9,19,30,31-tetrone
EINECS	Contact for details

Quality Control

Our 21-Hydroxyoligomycin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container under an inert atmosphere in a freezer. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.