Description

2,4,6-Triisopropylbenzenesulfonyl Fluoride is a specialized organosulfur compound featuring a sulfonyl fluoride functional group on a sterically hindered triisopropylbenzene core. This molecular architecture makes it a valuable reagent in synthetic organic chemistry, particularly for its role as a sulfonylating agent and as a precursor to other functionalized sulfonyl derivatives. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules and developing novel synthetic methodologies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing sulfonamide or sulfonate ester functionalities.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the sulfonyl fluoride group acts as a reactive handle.
• Chemical Biology Probe Development: Serves as a precursor for creating activity-based probes (ABPs) that target serine hydrolases and other enzymes in proteomic studies.
• Polymer & Material Science: Employed as a monomer or cross-linking agent in the development of specialty polymers, such as sulfonated polymers for ion-exchange membranes.
• Peptide Chemistry: Functions as a coupling reagent or protecting group derivative in solid-phase peptide synthesis (SPPS).
• Catalyst & Ligand Synthesis: Used to prepare sulfonated ligands for metal complexes in homogeneous catalysis.
• Organic Synthesis Reagent: Acts as a robust electrophile in nucleophilic substitution reactions to form C-S, N-S, and O-S bonds under mild conditions.
• Fluorination Agent Precursor: Can be transformed into other fluorinating reagents or used to introduce fluorine atoms into target molecules indirectly.

Basic Information

Product Name	2,4,6-Triisopropylbenzenesulfonyl Fluoride
CAS No.	101803-62-7
Molecular Formula	C15H23FO2S
Molecular Weight	286.41 g/mol
Synonyms	2,4,6-Triisopropylbenzenesulfonyl fluoride; 1,3,5-Triisopropyl-2-fluorosulfonylbenzene; 2-Fluorosulfonyl-1,3,5-triisopropylbenzene; TIPSF; Trisopropylbenzenesulfonyl fluoride; Benzenesulfonyl fluoride, 2,4,6-tris(1-methylethyl)-; 2,4,6-Triisopropylphenylsulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 2,4,6-Triisopropylbenzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.