Description

Olomoucine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs), specifically CDK1, CDK2, and CDK5. This compound matters as a critical research tool for studying cell cycle regulation, apoptosis, and signal transduction pathways in molecular biology and oncology research. It is needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer therapeutics, neurodegenerative diseases, and fundamental cell biology.

Application

• Biochemical Research: Used as a standard CDK inhibitor in enzymatic assays to study kinase activity and inhibition mechanisms.
• Cell Biology Studies: Employed to induce cell cycle arrest, typically at the G1/S or G2/M phase, for investigating cell proliferation and division.
• Oncology Research: Serves as a reference compound in cancer research for exploring tumor cell growth inhibition and apoptosis induction.
• Neurodegenerative Disease Models: Applied in research models for Alzheimer's and Parkinson's disease to study the role of CDK5 in neuronal death and tau protein phosphorylation.
• Drug Discovery & Development: Functions as a lead compound or pharmacological tool for screening and developing novel CDK-targeted therapeutic agents.
• Signal Transduction Pathway Analysis: Utilized to dissect and validate specific CDK-involved pathways in various cellular contexts.

Basic Information

Product Name	Olomoucine
CAS No.	101622-51-9
Molecular Formula	C15H18N6O
Molecular Weight	298.35 g/mol
Synonyms	2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine; 6-(Benzylamino)-2-[(2-hydroxyethyl)amino]-9-methyl-9H-purine; CGP 74514A; Roscovitine Analog; CDK Inhibitor II; Cyclin-Dependent Kinase Inhibitor Olomoucine
EINECS	Contact for details

Quality Control

Our Olomoucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure compliance with research-grade standards and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.