Description

(4-Azido-3-Iodobenzyl)Carazolol is a specialized chemical building block and research compound, primarily used as a photoaffinity labeling probe. This compound matters for its unique bifunctional structure, combining a carazolol moiety for β-adrenergic receptor targeting with a photoreactive azide group and a heavy atom (iodine) for detection. It is essential for researchers and pharmaceutical developers in the fields of medicinal chemistry, biochemistry, and molecular pharmacology who are studying receptor-ligand interactions, protein mapping, and drug discovery.

Application

• Photoaffinity Labeling Studies: Used as a covalent probe to capture and identify β-adrenergic receptor binding sites and other protein targets.
• Biochemical Research: A key tool for investigating G-protein-coupled receptor (GPCR) structure, function, and signaling pathways.
• Medicinal Chemistry & Drug Discovery: Serves as a precursor or intermediate in the development of novel β-blockers or diagnostic agents.
• Proteomics & Target Identification: Facilitates the isolation and characterization of drug-protein complexes for target deconvolution.
• Radioligand Development: The iodine atom provides a handle for potential radioiodination, creating probes for imaging or binding assays.
• Chemical Biology Tool Development: Enables the study of dynamic biological processes through light-induced cross-linking.

Basic Information

Product Name	(4-Azido-3-Iodobenzyl)Carazolol
CAS No.	101515-09-7
Molecular Formula	C24H27IN6O2
Molecular Weight	558.32 g/mol
Synonyms	4-Azido-3-iodobenzyl carazolol; Carazolol, 4-azido-3-iodobenzyl-; 1-(9H-Carbazol-4-yloxy)-3-[(2S)-2-hydroxy-3-[(4-azido-3-iodophenyl)methyl]amino]propyl]oxy]-2-propanol; 4-Azido-3-iodobenzyl derivative of carazolol; Photoaffinity carazolol probe; β-Adrenergic receptor photoaffinity label; AIBC; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (4-Azido-3-Iodobenzyl)Carazolol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR, and mass spectrometry for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere for long-term stability. This compound is light-sensitive and should be handled under subdued lighting conditions. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.