Description

n-Benzyloxycarbonylglycyl-Proline Diazomethyl Ketone is a specialized synthetic peptide derivative designed for advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and a potent, irreversible inhibitor for cysteine proteases, enabling precise study and modulation of enzymatic activity. It is essential for researchers and manufacturers in the fields of medicinal chemistry, proteomics, and drug discovery, particularly for developing therapeutic agents targeting conditions like inflammation, cancer, and parasitic diseases.

Application

• Protease Inhibitor Research: Acts as a potent, mechanism-based inhibitor for studying the function and structure of cysteine proteases such as cathepsins.
• Drug Discovery & Medicinal Chemistry: Serves as a key intermediate in the synthesis of novel therapeutic compounds targeting protease-related disorders.
• Biochemical Assay Development: Used to develop and validate high-throughput screening assays for identifying new protease inhibitors.
• Academic & Pharmaceutical R&D: A crucial tool for investigating enzyme kinetics, inhibition mechanisms, and structure-activity relationships (SAR).
• Peptide Synthesis: Employed as a specialized building block in the solid-phase or solution-phase synthesis of complex peptide analogs.

Basic Information

Product Name	n-Benzyloxycarbonylglycyl-Proline Diazomethyl Ketone
CAS No.	101412-97-9
Molecular Formula	C16H18N4O5
Molecular Weight	346.34 g/mol
Synonyms	Z-Gly-Pro-CHN2; Cbz-Gly-Pro-CHN2; Z-Gly-Pro-Diazomethyl Ketone; Benzyloxycarbonylglycyl-proline diazomethyl ketone; (Benzyloxycarbonyl)glycyl-L-proline diazomethyl ketone; Z-Gly-Pro diazomethane; Cbz-Glycyl-L-proline diazomethyl ketone; Protease Inhibitor Z-GP-CHN2
EINECS	Contact for details

Quality Control

Our n-Benzyloxycarbonylglycyl-Proline Diazomethyl Ketone is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This compound is strictly light-sensitive and hygroscopic; prolonged exposure to light, air, or moisture will lead to decomposition. Allow the container to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.