Description

Homohalichondrin B is a potent, structurally complex marine-derived macrolide with significant biological activity. This compound is a critical intermediate and reference standard in advanced pharmaceutical research, particularly in the development of novel anticancer therapeutics. It is essential for research institutions, pharmaceutical R&D laboratories, and biotechnology companies focused on oncology drug discovery and mechanism-of-action studies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant for analytical method development and validation in QC/QA laboratories.
• Oncology Research: Serves as a key biochemical tool for studying tubulin polymerization inhibition and its effects on cancer cell proliferation.
• Drug Discovery & Development: Acts as a crucial intermediate or lead compound in the synthesis and optimization of next-generation antitumor agents.
• Mechanistic Studies: Employed in preclinical research to investigate the structure-activity relationships (SAR) of halichondrin-class compounds.
• Biological Screening: Used in high-throughput screening assays to identify and evaluate new molecular targets and pathways.

Basic Information

Product Name	Homohalichondrin B
CAS No.	101383-39-5
Molecular Formula	C43H66O12
Molecular Weight	774.98 g/mol
Synonyms	Homohalichondrin-B; Norhalichondrin B; 6,7-Dihydrohalichondrin B; (1S,2S,4S,7R,8S,9S,12R,13R,15S,17S,18S,19S,21S,24S,26R,28R,30S,32S,33R,35S)-33-[(2S,3S)-3-[(2R,4S,5S,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-2-methylbutyl]-1,18,32-trihydroxy-19,30-dimethoxy-15,17,21,23,25,27,29,31-octamethyl-2,8,14,20,26-pentaoxa-11,34-dioxapentacyclo[31.2.1.14,7.09,13.018,21]hexatriacontane-3,10,16,22,28-pentone
EINECS	Contact for details

Quality Control

Our Homohalichondrin B is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container must be sealed under dry conditions and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.