Description

Propylglyoxal Bis(Guanylhydrazone) is a specialized guanylhydrazone derivative with significant biochemical research applications. This compound matters for its role as a potent and selective inhibitor of S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the polyamine biosynthesis pathway. Researchers in the pharmaceutical and life sciences sectors need it for investigating polyamine metabolism, which is crucial for understanding cell growth, proliferation, and developing potential therapeutic agents for cancer and parasitic diseases.

Application

• Biochemical Research: As a specific inhibitor of S-adenosylmethionine decarboxylase (AdoMetDC) for studying polyamine biosynthesis and regulation.
• Antiproliferative Studies: Used in in vitro and in vivo research to investigate the inhibition of tumor cell growth and proliferation.
• Parasitology Research: Applied in studies targeting polyamine metabolism in parasites like Trypanosoma and Plasmodium for potential antiparasitic drug discovery.
• Enzyme Kinetics: Serves as a tool compound for characterizing the activity and inhibition mechanisms of AdoMetDC.
• Reference Standard: Used as a high-purity analytical standard in method development and quality control for related pharmaceutical research.

Basic Information

Product Name	Propylglyoxal Bis(Guanylhydrazone)
CAS No.	100757-53-7
Molecular Formula	C8H20N10O2
Molecular Weight	288.31 g/mol
Synonyms	PGBC; Propylglyoxal Bis(Guanylhydrazone) Dihydrochloride (salt form); 1,1'-[1-Methyl-1,2-ethanediylidene]bis[2-guanylhydrazine]; AdoMetDC Inhibitor; S-Adenosylmethionine Decarboxylase Inhibitor; SAMDC Inhibitor; CGP 48664 (related analog); Guanylhydrazone derivative
EINECS	Contact for details

Quality Control

Our Propylglyoxal Bis(Guanylhydrazone) is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and determination of residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.