Description

2-(Trifluoromethyl)-6-Iodopyridine is a high-value, multi-functional halogenated pyridine derivative. This compound serves as a critical advanced pharmaceutical intermediate and versatile organic synthesis building block, prized for its unique trifluoromethyl and iodine substituents. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to introduce fluorinated aromatic systems into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the trifluoromethylpyridine moiety enhances biological activity and environmental stability.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for Suzuki-Miyaura, Stille, and Negishi cross-coupling reactions to form biaryl and heterobiaryl structures.
• Ligand and Material Precursor: Serves as a precursor for synthesizing specialized ligands for catalysis and as a monomer or building block for advanced organic electronic materials and liquid crystals.
• Fluorine Chemistry Research: An essential reagent in academic and industrial research exploring the effects of fluorine substitution on molecular properties like lipophilicity, metabolic stability, and binding affinity.
• Radiopharmaceutical Labeling: Potential use as a precursor for compounds where the iodine can be replaced with radioactive isotopes (e.g., I-123, I-125) for diagnostic imaging.

Basic Information

Product Name	2-(Trifluoromethyl)-6-Iodopyridine
CAS No.	100366-74-3
Molecular Formula	C6H3F3IN
Molecular Weight	272.99 g/mol
Synonyms	6-Iodo-2-(trifluoromethyl)pyridine; 2-Trifluoromethyl-6-iodopyridine; 6-Iodo-α,α,α-trifluoro-2-picoline; 2-Pyridinecarbonitrile, 6-iodo-α,α,α-trifluoro-; 2-Cyano-6-iodo-α,α,α-trifluorotoluene (related precursor); 6-Iodo-2-trifluoromethylpyridine; I-6-(Trifluoromethyl)pyridin-2-yl
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-6-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.