Description

Calpain Inhibitor VII is a potent, cell-permeable, and irreversible inhibitor of the calcium-dependent cysteine proteases calpain I and II. This compound is a critical research tool for elucidating the role of calpain activity in cellular processes such as apoptosis, signal transduction, and cytoskeletal remodeling. It is essential for researchers in pharmaceutical development, neuroscience, and cardiovascular disease studies, providing a reliable means to investigate pathological mechanisms and validate therapeutic targets.

Application

• Biomedical Research: Fundamental tool for studying calpain-mediated pathways in cell culture and animal models of disease.
• Neurodegenerative Disease Studies: Investigation of calpain's role in conditions like Alzheimer's disease, Parkinson's disease, and traumatic brain injury.
• Cardiovascular Research: Exploration of myocardial ischemia-reperfusion injury, atherosclerosis, and heart failure mechanisms.
• Muscular Dystrophy Research: Analysis of calpain-3 function and its implications in limb-girdle muscular dystrophy.
• Cancer Biology: Research into calpain involvement in tumor cell migration, invasion, and metastasis.
• Drug Discovery & Validation: Used as a reference standard and pharmacological probe in high-throughput screening and target validation assays.

Basic Information

Product Name	Calpain Inhibitor VII
CAS No.	100241-76-7
Molecular Formula	C₂₀H₃₈N₄O₄
Molecular Weight	398.54 g/mol
Synonyms	MDL 28170; Z-Val-Phe-CHO; Z-Val-Phe-H; Carbobenzoxy-Val-Phe-H; Calpain Inhibitor III; (S)-2-(((S)-1-((Benzyloxy)amino)-3-methyl-1-oxobutan-2-yl)amino)-N-((S)-1-oxo-3-phenylpropan-2-yl)formamide; N-[(Benzyloxy)carbonyl]-L-valyl-N-[(1S)-1-formyl-2-phenylethyl]-L-alaninamide
EINECS	Contact for details

Quality Control

Our Calpain Inhibitor VII is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of academic and pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.