Description

α-Etoposide CAS NO 100007-53-2 is a semi-synthetic derivative of podophyllotoxin, belonging to the class of topoisomerase II inhibitors. This compound is critically important for its potent antineoplastic activity, which is essential for disrupting cancer cell proliferation. It is primarily required by the pharmaceutical industry for the research, development, and manufacturing of chemotherapeutic agents targeting various cancers, including testicular and small-cell lung carcinomas.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of injectable and oral chemotherapeutic drugs.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research for studying the mechanisms of topoisomerase II inhibition and DNA damage response in cancer cells.
• Preclinical Development for in vitro and in vivo efficacy and toxicity studies of new oncology treatments.
• Pharmaceutical Intermediates for the synthesis of more complex anticancer drug candidates.

Basic Information

Product Name	α-Etoposide
CAS No.	100007-53-2
Molecular Formula	C29H32O13
Molecular Weight	588.56 g/mol
Synonyms	Etoposide; VP-16; VP-16-213; 4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]; (5R,5aR,8aR,9S)-5-[[4,6-O-[(1R)-Ethylidene]-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; ETOPOPHOS (phosphate prodrug); VePesid; Lastet.
EINECS	Contact for details

Quality Control

Our α-Etoposide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and residual solvent analysis to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.