Description

6-o-Benzylguanine is a potent and selective inhibitor of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT). This compound is a critical research tool and pharmaceutical intermediate, enabling the study of DNA repair mechanisms and the development of targeted cancer therapies. It is essential for researchers and manufacturers in the fields of oncology, molecular biology, and medicinal chemistry who require high-purity biochemicals for advanced applications.

Application

• AGT Inhibition Studies: Used as a standard inhibitor in biochemical and cellular assays to study the function and kinetics of the O6-alkylguanine-DNA alkyltransferase DNA repair enzyme.
• Cancer Research: A key component in research exploring combination therapies, where it is used to sensitize tumor cells to the effects of alkylating chemotherapeutic agents like temozolomide.
• Prodrug Development: Serves as a foundational scaffold and intermediate in the synthesis of antibody-directed enzyme prodrug therapy (ADEPT) and other targeted therapeutic platforms.
• Mechanistic Pharmacology: Employed to investigate DNA damage response pathways and resistance mechanisms in various cancer cell lines.
• Reference Standard: Utilized as a high-purity analytical standard in pharmaceutical quality control and method development for related compounds.

Basic Information

Product Name	6-o-Benzylguanine
CAS No.	19916-73-5
Molecular Formula	C12H11N5O
Molecular Weight	241.25 g/mol
Synonyms	O6-Benzylguanine; 6-Benzyloxyguanine; O6-BG; NSC 637037; 2-Amino-6-(benzyloxy)-9H-purine; 6-(Benzyloxy)-9H-purin-2-amine; AGT Inhibitor O6-Benzylguanine
EINECS	Contact for details

Quality Control

Our 6-o-Benzylguanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.