Description

2,3,5,6-Tetrafluorobenzaldehyde is a versatile fluorinated aromatic aldehyde, a key building block in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the tetrafluoro substitution pattern, which makes it an essential intermediate for creating complex molecules with enhanced stability and performance. This compound is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), where fluorine atoms are used to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used to manufacture advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms to improve lipophilicity and environmental persistence of the final product.
• Liquid Crystal & OLED Materials: Serves as a key building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved charge transport and thermal stability.
• Polymer & Resin Modifier: Incorporated into polymer backbones to create high-performance resins with enhanced chemical resistance, lower dielectric constants, and improved weatherability.
• Cross-coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems for material science and drug discovery.
• Ligand & Catalyst Development: Used to synthesize novel fluorinated ligands for catalysis, which can lead to more efficient and selective industrial chemical processes.

Basic Information

Product Name	2,3,5,6-Tetrafluorobenzaldehyde
CAS No.	19842-76-3
Molecular Formula	C7H2F4O
Molecular Weight	178.09 g/mol
Synonyms	2,3,5,6-Tetrafluorobenzaldehyde; Benzaldehyde, 2,3,5,6-tetrafluoro-; Perfluorobenzaldehyde (historical); TFBAL; 2,3,5,6-Tetrafluorobenzenecarboxaldehyde; α,α,α,α-Tetrafluorobenzaldehyde; Tetrafluorophthalaldehyde (isomer specific); NSC 406925
EINECS	243-356-5

Quality Control

Our 2,3,5,6-Tetrafluorobenzaldehyde is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to light and tendency for oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.