Description

9-Methoxycamptothecin is a potent semi-synthetic derivative of the natural alkaloid camptothecin, known for its significant antitumor activity. This compound is a critical intermediate and reference standard in pharmaceutical research and development, primarily due to its role as a topoisomerase I inhibitor. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors focused on developing novel chemotherapeutic agents and conducting advanced pharmacological studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of more complex camptothecin analogs and novel anticancer drug candidates.
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) and research laboratories for method development, validation, and compound identification via HPLC, LC-MS, or NMR.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate mechanisms of topoisomerase I inhibition, apoptosis induction, and cell cycle arrest.
• Anticancer Agent Development: A core structure for structure-activity relationship (SAR) studies aimed at improving solubility, efficacy, and reducing side effects of camptothecin-based therapies.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry, oncology, and molecular biology.

Basic Information

Product Name	9-Methoxycamptothecin
CAS No.	19685-10-0
Molecular Formula	C21H18N2O5
Molecular Weight	378.38 g/mol
Synonyms	9-MCPT; 9-Methoxy-20(S)-camptothecin; (S)-9-Methoxycamptothecin; 9-Methoxy-20(S)-camptothecine; NSC 176323; 9-Methoxy-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
EINECS	Contact for details

Quality Control

Our 9-Methoxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the (S)-configuration, and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with detailed results for all critical parameters, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0% (S-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.