Description

Wortmannin CAS NO 19545-26-7 is a potent, cell-permeable, and irreversible inhibitor of phosphatidylinositol 3-kinase (PI3K) and related kinases. This specificity makes it a critical research tool for elucidating the PI3K/AKT/mTOR signaling pathway, which is fundamental to cellular processes like growth, proliferation, and survival. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for biochemical research, target validation, and drug discovery programs.

Application

• Biochemical Research: A standard tool for studying the role of PI3K in signal transduction pathways.
• Cancer Research: Used to investigate tumor cell proliferation, survival, and angiogenesis by inhibiting PI3K activity.
• Immunology Studies: Applied to explore immune cell activation and inflammatory responses mediated by PI3K signaling.
• Metabolic Disorder Research: Employed in studies related to insulin signaling and glucose metabolism.
• Neuroscience Research: Utilized to examine neuronal survival, growth, and synaptic plasticity.
• Drug Discovery & Target Validation: Serves as a pharmacological probe to validate PI3K as a therapeutic target in preclinical models.
• Cell Culture & In Vitro Assays: Used to modulate PI3K activity in various cell-based experimental systems.

Basic Information

Product Name	Wortmannin
CAS No.	19545-26-7
Molecular Formula	C23H24O8
Molecular Weight	428.43 g/mol
Synonyms	11β,15α-Epoxy-3β,8α,9α,11α-tetrahydroxy-14-oxo-5β,13α-androsta-1,6-dien-17β-carboxylic Acid 17-Lactone; (1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione; PI3K Inhibitor Wortmannin; Kyowa Hakko 1249
EINECS	Contact for details

Quality Control

Our Wortmannin is produced and tested under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity determination by HPLC. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.