Description

N(2)-Ethylguanine is a modified nucleobase derivative of guanine, where an ethyl group is substituted at the N2 position. This specific alkylation makes it a valuable reference standard and synthetic intermediate in biochemical and pharmaceutical research. It is primarily utilized by researchers and manufacturers in the fields of oncology, molecular biology, and medicinal chemistry. The compound is essential for studying DNA adducts, mutagenesis, and for the development of novel therapeutic agents.

Application

• Biochemical Research Standard: Used as a high-purity reference material in analytical laboratories for the identification and quantification of DNA alkylation damage.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of nucleoside analogs and potential chemotherapeutic agents.
• Toxicology Studies: Employed in metabolic and genotoxicity studies to understand the biological impact of ethylating agents and environmental toxins.
• Academic Research: Fundamental tool in universities and research institutes for investigating DNA repair mechanisms and mutagenic pathways.
• Diagnostic Development: Can be used in the development of assays and kits designed to detect specific DNA lesions for diagnostic purposes.

Basic Information

Product Name	N(2)-Ethylguanine
CAS No.	19545-00-7
Molecular Formula	C7H9N5O
Molecular Weight	179.18 g/mol
Synonyms	2-Ethylguanine; N2-Ethylguanine; Guanine, N(2)-ethyl-; 2-Amino-6-ethoxy-purine; 9H-Guanin-2-yl-ethylamine; 2-Ethyl-1,9-dihydro-6H-purin-6-one; 2-Ethyl-9H-purin-6-ol
EINECS	Contact for details

Quality Control

Our N(2)-Ethylguanine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality system is designed to meet the rigorous standards required for reference materials and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.