Description

Bay 11-7082 is a potent and selective small molecule inhibitor of IκBα phosphorylation, which effectively blocks NF-κB activation. This compound is a critical research tool for studying inflammatory signaling pathways, apoptosis, and cellular responses to stress. It is primarily utilized by researchers and scientists in the pharmaceutical, biotechnology, and academic sectors for drug discovery and mechanistic studies.

Application

• Biomedical Research: A key reagent for investigating the NF-κB signaling pathway and its role in inflammation, immune response, and cancer.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and target validation studies.
• Cell Biology Studies: Employed to induce or study apoptosis, cell proliferation, and cytokine production in various cell lines.
• Inflammatory Disease Models: Applied in preclinical research to model and understand conditions like rheumatoid arthritis, asthma, and atherosclerosis.
• Academic Research: Essential for university and institutional labs conducting fundamental research in molecular biology and biochemistry.

Basic Information

Product Name	Bay 11-7082
CAS No.	19542-67-7
Molecular Formula	C16H14N2O3S
Molecular Weight	314.36 g/mol
Synonyms	(E)-3-(4-Methylphenyl)sulfonyl-2-propenenitrile; BAY 11-7082; BAY 11-7085; BAY11-7082; IKK-2 Inhibitor IV; NF-κB Activation Inhibitor; (E)-3-[4-(Methylsulfonyl)phenyl]-2-propenenitrile; 3-[(E)-2-Cyanoethen-1-yl]benzenesulfonamide
EINECS	Contact for details

Quality Control

Our Bay 11-7082 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.