Description

Catechol, [14C(U)] is a carbon-14 radiolabeled derivative of catechol (1,2-dihydroxybenzene), a fundamental aromatic compound. This isotopically labeled version is essential for precise metabolic and environmental fate studies, providing critical data for regulatory submissions and scientific research. It is primarily utilized by pharmaceutical, agrochemical, and environmental research organizations engaged in advanced tracer studies, drug metabolism and pharmacokinetics (DMPK) research, and biodegradation pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of new chemical entities in preclinical development.
• Environmental Fate and Biodegradation Research: Investigating the breakdown pathways and persistence of catechol-based compounds or pollutants in soil and water systems.
• Biochemical Pathway Elucidation: Serving as a tracer in studies of enzymatic processes, such as those involving catechol-O-methyltransferase (COMT).
• Agrochemical Research: Studying the metabolic fate and residue analysis of pesticides or herbicides that degrade into or are derived from catechol structures.
• Synthesis of Labeled Compounds: Used as a radiolabeled building block for the synthesis of more complex carbon-14 labeled molecules for research.

Basic Information

Product Name	Catechol, [14C(U)]
CAS No.	19481-10-8
Molecular Formula	C6H614C2O2 (or [14C(U)]C6H6O2)
Molecular Weight	~112.1 g/mol (varies with specific activity)
Synonyms	1,2-Benzenediol, [14C(U)]; 1,2-Dihydroxybenzene, [14C(U)]; Pyrocatechol, [14C(U)]; o-Benzenediol, [14C(U)]; o-Dihydroxybenzene, [14C(U)]; 2-Hydroxyphenol, [14C(U)]; Radiolabeled Catechol; Carbon-14 Labeled Catechol
EINECS	Contact for details

Quality Control

Every batch of Catechol, [14C(U)] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as radiochemical purity (typically >97% by HPLC), specific activity, chemical purity, and solvent composition. Our quality commitment aligns with the stringent requirements for radiolabeled compounds used in GLP-compliant and regulatory studies.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as specified on the label. This product is both light-sensitive and easily oxidized; storage under inert atmosphere in a dedicated freezer for radioactive materials is recommended. Always adhere to local and institutional regulations for the handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC)	Retention time corresponds to reference standard
Specific Activity	Customizable (e.g., 50-60 mCi/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol, Toluene, or as specified
Concentration	1.0 mCi/mL (or as customized)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.