Description

Adenosine Monophosphofluoridate is a specialized nucleotide analog that serves as a potent and selective inhibitor of adenylate cyclase, a key enzyme in cellular signaling pathways. This compound is crucial for researchers investigating G-protein coupled receptor (GPCR) function, cyclic AMP (cAMP) metabolism, and signal transduction mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic biochemists, and contract research organizations (CROs) focused on metabolic and cardiovascular disease research.

Application

• Biochemical Research: As a tool compound for studying adenylate cyclase inhibition and cAMP-dependent signaling cascades in vitro.
• Pharmaceutical Development: Used in target validation and screening assays for drug discovery programs targeting GPCRs and metabolic disorders.
• Enzymology Studies: Serves as a substrate analog to investigate the kinetics and mechanism of adenylate cyclase and related nucleotide-processing enzymes.
• Cell Signaling Pathway Analysis: Employed to modulate intracellular cAMP levels to dissect downstream effects in cardiac, neural, and endocrine cell models.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Adenosine Monophosphofluoridate
CAS No.	19375-33-8
Molecular Formula	C10H14FN5O6P
Molecular Weight	365.22 g/mol
Synonyms	AMP-Fluoridate; Adenosine 5'-(Fluorophosphonate); 5'-O-[Fluorophosphono]adenosine; Adenosine 5'-Monophosphofluoridate; Fluorophosphoryl Adenosine; P1-(5'-Adenosyl) P2-fluorophosphonate; 9-β-D-Ribofuranosyladenine 5'-(fluorophosphonate); Adenyl-5'-yl Fluorophosphonate
EINECS	Contact for details

Quality Control

Our Adenosine Monophosphofluoridate is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC purity analysis, NMR spectroscopy for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.